![]() ![]() During this medical trial, not only the efficiency of stem cells will be tested, but also the safety of this new form of treatment. They will receive a new investigational drug in a few months’ time, shortly after the study begins.Įnrolment for this trial will begin before the end of this year. This approval will allow 18 patients suffering from the Lou Gehrig´s disease to have access to this innovative technique. Food and Drug Administration (FDA) to use Stem Cells and Gene therapy in order to slow down and even stall the progression of Amyotrophic Lateral Sclerosis. For instance, the Los Angeles based Cedar-Sinai Medical Center has been granted permission by the U.S. Moreover, all the members of our medical team were happy to find out that there are currently trials being conducted in several countries around the world. From our partner hospital in Bangkok, we have witnessed the improvements our doctors report on a weekly basis. Unique Access Medical is proud of being one of the leading companies in the industry, helping patients to access receive the most advanced Stem Cell Therapies for ALS patients and a global player in terms of treatment quality. The improvements have been noticeable and the satisfaction among those that have received our therapies is ranked really high. However, the use of Stem Cell Treatments is becoming increasingly widespread and with it comes potential improvement.Īt our hospital in Bangkok, Thailand, we have been successfully providing patients with some of the finest stem cell treatments available to those who are unfortunate enough to suffer from ALS. People who suffer from this devastating disease are given little hope by doctors who tell them that they have to face imminent death. Published by Elsevier Inc.There are few conditions that are as lethal and degenerative as Amyotrophic Lateral Sclerosis. Pre-clinical data leading to these trials, as well as those in development are also evaluated in terms of mechanisms of action, validity of conclusions and rationale for advancing stem cell treatment strategies for this devastating disorder.ĪLS Amyotrophic lateral sclerosis Clinical trials Motor neuron disease Neurodegenerative disorder Stem cell therapy Stem cells Transplantation.Ĭopyright © 2014. Here, we provide a critical review of current clinical trials using either mesenchymal or neural stem cells to treat ALS patients. However, given our poor understanding of what causes ALS and whether stem cells may ameliorate symptoms, there should be a push to determine cell safety in pre-clinical models and then a quick translation to the clinic where patient trials will show if there is any efficacy. Prior to moving into patients, stringent pre-clinical studies are required that have at least some rationale and efficacy in animal models and good safety profiles. This could be through reducing inflammation, releasing growth factors, and other potential less understood mechanisms. While motor neuron replacement remains a focus of some studies trying to treat ALS with stem cells, there is more rationale for using stem cells as support cells for dying motor neurons as they are already connected to the muscle. However, in recent years stem cell transplantation has emerged as a potential new therapy for ALS patients. Without understanding what causes ALS it is difficult to design treatments. While the genetics of ALS are becoming more understood in familial cases, the mechanisms underlying disease pathology remain unclear and there are no effective treatment options. This leads to paralysis, respiratory insufficiency and death within an average of 3 to 5 years from disease onset. ![]() Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that is characterized by progressive degeneration of motor neurons in the cortex, brainstem and spinal cord. ![]()
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